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Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

Likelihood assessment of vaccine-induced (epi-)myocarditis. Causality or correlation? Presence of myocarditis with temporal association to vaccination event AND Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis

Abstract infographic: Cases of myocarditis

Have been diagnosed clinically, by laboratory tests, imaging (in the context of mRNA-based anti-SARS-CoV-2 vaccination) Autopsy-based description We describe, Cardiac autopsy findings and common characteristics of myocarditis, with vaccine-induced myocardial inflammation representing the likely or possible cause of death. Our findings establish the histological phenotype of lethal vaccination-associated myocarditis.

Standardized autopsies

Performed on 25 persons

25 bodies found unexpectedly dead at home, within 20 days following SARS-CoV-2 vaccination


Patchy, focal, interstitial myocardial T-lymphocytic and macrophage infiltration, predominantly of the CD4 positive sub- set, (T Helper cells) associated with mild myocyte damage.

Autopsy findings indicated:

Death due to acute arrhythmogenic cardiac failure. Thus, Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination, and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.



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