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Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

Likelihood assessment of vaccine-induced (epi-)myocarditis. Causality or correlation? Presence of myocarditis with temporal association to vaccination event AND Integration of histological phenotype, clinical presentation, and laboratory findings indicate no alternative differential diagnosis


Abstract infographic: Cases of myocarditis


Have been diagnosed clinically, by laboratory tests, imaging (in the context of mRNA-based anti-SARS-CoV-2 vaccination) Autopsy-based description We describe, Cardiac autopsy findings and common characteristics of myocarditis, with vaccine-induced myocardial inflammation representing the likely or possible cause of death. Our findings establish the histological phenotype of lethal vaccination-associated myocarditis.


Standardized autopsies

Performed on 25 persons

25 bodies found unexpectedly dead at home, within 20 days following SARS-CoV-2 vaccination


Histology

Patchy, focal, interstitial myocardial T-lymphocytic and macrophage infiltration, predominantly of the CD4 positive sub- set, (T Helper cells) associated with mild myocyte damage.


Autopsy findings indicated:

Death due to acute arrhythmogenic cardiac failure. Thus, Myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination, and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.


STUDY:

https://link.springer.com/article/10.1007/s00392-022-02129-5#Sec3


RELATED ARTICLE:

https://petermcculloughmd.substack.com/p/found-dead-at-home-after-covid-19


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